Efforts to find a vaccine for Ebola have taken a significant step forward this week after initial tests on humans showed promising results according to research published in the Lancet.
Results from the first phase 1 trials of the vaccine against the strain of Ebola that killed tens of thousands of people in western African last year shows it provoked a response from the participants immune system.
This was the first test of a vaccine carried out on the most recent strain of the virus, rather than the strain associated with an earlier outbreak in Zaire in the 1970s.
In the latest study, participants who received a higher dose of the vaccine produced higher quantities of antibodies than those who received a lower dose. A placebo was given to a control group who showed no immune response.
However scientists at the Beijing Institute of Biotechnology and the Tianjin CanSino Biotechnology, both in China, have warned that it is early days and it is not possible to say for sure if the immune response exhibited in participants would be enough to destroy the virus.
They said further testing will be required in Africa to establish whether it could protect against Ebola and they also need to investigate the possibility the vaccine may increase the risk of contracting the HIV virus, which has been suggested in previous research.
Professor Fengcai Zhu, who led the researchers, said: “On the basis of our findings, we believe that the Ebola vaccine we assessed has some potential, and a significant advantage of this type of vaccine is that stable and much easier to store or transport in tropical areas with inadequate cold-chain capacity, such as Africa. However, whether this candidate vaccine could become a final vaccine for widespread use against Ebola outbreaks is still uncertain, because of the issues of HIV-1 acquisition rates and the pre-existing immunity, especially in west Africa.
They believe the world might become ‘a happier and healthier place’ if these drugs were more widely available because of their links to treatment for alcoholism and post-traumatic stress disorder (PTSD).
Originally posted on The Honest Courtesan:
Dr. Paul Maginn is an Associate Professor of Urban Planning at the University of Western Australia; he is the co-editor and co-author of several chapters in the recently published book (Sub)Urban Sexscapes: Geographies and Regulation of the Sex Industry. I asked him to comment on his book and explain why a planner & geographer is so interested in sex work.
At social events whenever we meet someone new for the first time it can be guaranteed that they will ask, “So, what do you do for a living?” In the past, my stock response was generally: “I’m an academic…an urban planner”! The stock replies to this usually range from: “Oh! What does that mean?” to “Oh, that’s nice! I have to go now because there’s my friend over there”. You see, being an academic doesn’t seem to capture too many non-academic peoples’ attention. So nowadays, when I’m asked what…
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Back when I was City journalism student learning about health reporting – and later a copywriter for health charities – the sensitivity of language around medical subjects was drilled into me by various experts in fields such as mental health, HIV, and TB. The choice of terminology determines the tone of an article and sometimes even the journalist can be unaware of the implications of the language they’re using – something I often see as a freelance sub-editor of tabloid news.
The biggest mistakes do tend to appear in tabloid press, although all health journalists have a responsibility to find a middle ground between rigid medical terminology and the more illustrative language of journalism. But according to a guidance paper published by a a group of journal editors last week, scientists don’t always get it right either.
Editors of the journal Substance Abuse were apparently so concerned at some of the terms found in submitted papers they published an article appealing for researchers to use language that ‘respects the worth and dignity of all people…focuses on the medical nature of substance use…and avoids perpetuating negative stereotypes and biases through the use of slang and idioms’.
Some of the ‘what not to do’ examples sound like they could have come out of a column of a judgemental newspaper editorial:
“Although it is perhaps surprising, our journal has received submissions that contain explicitly morally laden language, e.g., referring to the “depraved and degenerate lives” of individuals who use substances,” wrote the Substance Abuse editors. They also revealed that some submissions included slang words such as ‘addicts’, ‘speedball’, and ‘clean’/’dirty’ urine.
Less obvious, but equally important, was the advice on using ‘people-ﬁrst’ language, and highlighting that a person’s condition is only one aspect of them and not their defining characteristic. ‘Addicts’, ‘users’, or ‘alcoholics’ are terms, according to the authors, that erase individual differences and presumes an homogeneity in experiences. They advise instead on using: ‘person with a ‘cocaine use disorder’ or ‘adolescent with an addiction’.
By the same token, they suggest that referring to a convict by their crime – murderer, drug dealer, thief – may be dehumanising. Instead they advice using the terms ‘people in prison’ or ‘people on parole’, a phrase perhaps suitable for scientific papers but not one I can ever see getting past a newspaper editor (although I did recently read an article that used the phrase ‘people with vaginas’).
They also turn the mirror on to themselves however, acknowledging that the very title of the journal they’re editing – Substance Abuse – could be deemed pejorative, referencing addiction expert William L. White’s article The Rhetoric of Recovery Advocacy: An Essay On the Power of Language.
In his essay, White writes that “of all the words that have entered the addiction/treatment vocabulary, ‘abuse’ is one of the most ill-chosen” and “to suggest that the addict mistreats the object of his or her deepest affection is a ridiculous notion”. He argues this word comes from an historic religious and moral concept of addiction and can be compared to the now – thankfully – defunct term ‘self-abuse’ that was once used to describe masturbation.
Both White and the Substance Abuse authors agree however that people recovering from these conditions are really the ones who should shape their own language and definitions.
“Most importantly, we need to know much more about the thoughts and preferences of the individuals and families who are affected by drug and alcohol use: how do they feel about
their own and others’ use of the terminology discussed above? What language would they like us to use, and what are the implications for the services and policies they need?” the journal editors ask.
To summarise, I’ll borrow a fitting quote from the introduction to White’s paper (that he borrowed himself nonetheless):
“The difference between the right word and the almost right word is the difference between lightning and the lightning bug.” – Mark Twain
The battle to curb HIV infections in some regions of Europe is failing after new figures released last week show an 80 percent increase in the rate of infection in 2013 when compared to 2004.
The vast majority of new cases occur in Eastern Europe and Central Asia, which has seen a two fold surge of HIV infections in the past decade, thought to be due to insufficient policies in many countries aimed at preventing the spread of infection among drug users and men who have sex with men.
The latest figures released by the European Centre for Disease Prevention and Control (ECDC) and the World Health Organisation Regional Office for Europe show that in 2013 there were 176,000 new HIV diagnosis, a huge increase from the 79,000 new cases that were registered in 2004.
Over 100,000 of the new cases in 2013 were registered in Eastern Europe and Central Asia, one of the few regions around the world were HIV infections continue to rise.
The lack of harm reduction programmes in drug policies, particularly needle exchange programmes, is thought to be partly responsible for the surge in infections in this region. However disease prevention experts point out that some of the main people affected across all of Europe are still men who have sex with men.
“The number of HIV diagnoses among this group has increased by 33% compared to 2004 – and has been going up in all but four EU/EEA countries. This is why prevention and control of HIV among men who have sex with men has to be a cornerstone of national HIV programmes across Europe,” explains ECDC Director Marc Sprenger.
Across much of this region there aren’t many programmes designed to specifically target and support the LGBT communities, which can partly be due to societal attitudes towards homosexuality that can make it difficult for to seek treatment. For example a 2009 European Social Survey found that the level of acceptance of the statement “gay men and lesbians should be free to live their own life as they wish” was lowest in former Soviet bloc countries.
A 2012 study looking at the experience of gay HIV positive men in Hungary found that many avoided being discriminated against by keeping their HIV status secret. One interviewee said: “If the whole town knows about my HIV status, then the dentist won’t have me and people will avoid me on the street. … So, I never inform anyone about my HIV status and, even if someone would directly ask about it, I wouldn’t say anything because it is none of their business.”
And researchers found that when the men were required to disclose their status to medics and hospital staff it was then they faced the strongest discrimination, with one nurse telling a patient to wash themselves because “she didn’t know how the disease spread” and even doctors encouraging someone to keep their status a secret.
Experts say the increasing rates of HIV infection and the societal problems that often surround the epidemic can be tackled with effective education campaigns backed up by strong policies and funding for testing and treatment programmes. And what better day to think about the road ahead than today – World AIDS Day – which this year is campaigning under the slogan “Focus, Partner, Achieve: An AIDS Free Generation.”
Since leaving London and setting up as a freelancer here in Vienna, I’ll admit that I’ve found myself with much more time on my hands than I’ve been used to. But having this extra time means I can browse the internet at a much more leisurely pace, resulting in the discovery of some fantastic free online resources. This ‘Daily German’ website’s online course has given a great kickstart to my German learning. And just last week I also signed up to this free data journalism course from the European Journalism Centre, starting in January.
On a more health related note, health sector professionals in low income countries or working with limited resources might find this online course useful:
Called eSCART, it’s a 4 month distance learning course that aims to provide people with the knowledge they need to treat HIV patients with antiretroviral therapy (ART) in resource limited settings. It’s tutor-led, and also provides access to a discussion forum where those who signed up can discuss their learning with other ‘classmates’. It has 13 modules including an introduction to HIV, HIV and TB, side effects and monitoring and evaluation of an ART programme. Not bad for a free course that just needs an internet connection and a computer with speakers (and a brain connected to it might help too!).
For other free online global health courses check out this handy resource called Global Health elearning. From family planning and childhood development to health logistics and infectious diseases, this is a gold mine for professors or students looking for global health education resources, or just health professionals wanting to bolster their knowledge or train other staff.
Last month, I joined Public Health Perspective (PHP) Nepal as a contributing writer. PHP Nepal is a public health online newsletter that publishes articles about health information, ideas and innovation from around the world and I’ve just written my first piece for them on the global pandemic of counterfeit medicines. Pop across to PHP Nepal to find out about some of the interesting technologies being used to tackle this trade:
For countries already struggling under the burden of multiple health problems, counterfeit and sub-standard medicines are a dangerous and very unwelcome addition. Although many drugs that get counterfeited are lifestyle drugs, such as Viagra, it is the proliferation of fake anti-malarials and medicines for other infectious diseases in low income countries that can devastate lives… (continue reading on Public Health Perspective Nepal)